Some of the premier and biggest casinos in Sin City have tons of slots games and while all give the house an edge there are some that have better returns than others.Ĭheck out the best online cansinos in the us There is no lack of great casinos in Las Vegas, but you may ask yourself, what is the best casino in Vegas to win and which casino in Vegas pays out the best? Good questions, for sure, but you have to know whatever casino you go into the house always has the edge.